UJI AKTIVITAS ANTIBAKTERI NANOPARTIKEL EKSTRAK ETANOL DAUN MATOA (Pometia pinnata J.R. Forst & G. Forst) TERHADAP BAKTERI Escherichia coli

Escherichia coli was one of the bacteria that causes diarrhea. Matoa leaves (Pometia pinnata J.R. Forst & G. Forst) ) is a plant from Sapindaceae family and known to have antibacterial compounds. This study aims make ethanol extract matoa into nanoparticles determine activity better than against E. bacteria.
 research conducted experimentally with free variables, namely concentration leaf (KEDM 25%; KEDM 50%; 75%), nanoparticle (KNDM 2.5%; KNDM 5%; 7.5%). The bound variable bacteria. Nanoparticle manufacturing uses ionic glassing method chitosan 0.1% Na-TPP (1:1). size characterization used Particle Size Analyzer (PSA). Antibacterial test using diffusion Kirby Bauer's agar. 
 result obtained 324.97 nm. value Zone Of Inhibition (ZOI) 13.9 mm 25%); 14.6 50%); 18 75%). ZOI 6.6 2.5%); 7.2 5%); 7.7 conclusion this can be as an nanoparticle, where 2.5% already has capability which equivalent half dose 25% leaves, so it said preparation reduce drug by up dose, even though in resistant category compared Tetracycline 30 μg.